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Ms. Hellfire may refer to:
- Ms. Hellfire (episode), the 9th episode of season 2 and 31st episode in total of The WB's Charmed in which Barbas returns and Prue poses as a hit-woman.
- Ms. Hellfire (character), a hit-woman hired by Bane Jessup, who was hired by Barbas, to kill thirteen unmarried witches by midnight on a Friday the 13th.